Background

The origin

Before founding Dicot AB, Jarl Wikberg, was a professor at the Department of Pharmaceutical Biosciences at Uppsala University in the early 2000s. During a conference in South Africa, he met Dr Philippe Rasoanaivo, Professor at the Institut Malgache des Recherches Appliquées in Madagascar. Dr Rasoanaivo spoke about his research on the traditional medicine’s use of plants and roots. His particular interest was in plants used to treat failing sexual ability in older men.

Dr Wikberg, who was an expert on pharmacologically active substances that could affect sexual function, became fascinated and suggested a research collaboration. In initial experiments in Uppsala, various botanical extracts were prepared and given to laboratory animals, whereupon Prof. Wikberg found that the animals became more sexually active with some of these extracts.

Discovering Libiguin

Dr Wikberg wanted to investigate whether there was a pharmacologically active substance in the preparations that triggered the effect, which could thus be reproduced as a semi-synthetic pharmaceutical product. Research resulted in the isolation of two previously unknown substances; Libiguin A and Libiguin B. In follow-up studies in rats, both substances proved to have strongly potent effects on their sexual behaviour.

Due to the ability to synthesise Libiguin, the attention was turned to plants in southern Africa that contain a closely related but inactive molecule. Through a semi-synthesis via a few short steps, it could be converted into the active substance Libiguin.

The Path Forward – Developing LIB-01 into a Marketed Drug

Research and data generated since its discovery indicate that Libiguin has great potential to provide long-term improvement in sexual dysfunctions in men. Dr. Jarl Wikberg founded Dicot AB in 2015 to develop Libiguin into a pharmaceutical treatment. Since then, further research and development have been conducted, including preclinical and clinical studies, manufacturing process development, and patent work.

The drug candidate is now called LIB-01, and Dicot’s work continues systematically and sustainably to complete the pharmaceutical development program with the goal of introducing a groundbreaking erectile dysfunction treatment to the global market.

About the company name Dicot

Dicot is a short version of dicotyledon, a Latin term meaning dicotyledonous flowering plant - herb, flowers or trees that have two leaves when germinating, as opposed to a monocot (a monocotyledon) plant which has only one leaf when germinating e.g. grasses, palm trees, ferns, bracken etc.